9-Phenanthrol

SKU: orb1940386

Description

9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.(In Vitro):In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5.

Key Properties

• CAS Number: 484-17-3
• MW: 194.233
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₀O
• SMILES: Oc1cc2ccccc2c2ccccc12
• Target: TRP/TRPV Channel
• Solubility: In Vitro: DMSO : 100 mg/mL (514.85 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TRP/TRPV Channel