9-CP-Ade Mesylate

SKU: orb1703868

Description

9-CP-Ade Mesylate is a cell-permeable, non-competitive adenylate cyclase inhibitor used in research. Its stability makes it suitable for both in vitro and in vivo studies to investigate cAMP-mediated signaling pathways in cellular physiology and pharmacology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 189639-09-6
• MW: 299.35
• Purity: 99.81% (May vary between batches)
• Formula: C₁₁H₁₇N₅O₃S
• SMILES: CS(O)(=O)=O.Nc1ncnc2n(cnc12)C1CCCC1
• Target: Adenylate cyclase
• Solubility: DMSO:29.94 mg/mL (100.02 mM)

Bioactivity

• In Vitro:
  9-CP-Ade Mesylate (200 μM; 30 min) inhibits cAMP response element binding protein (CREB) activation and completely blocks neurogenesis in PC12 cells. 9-CP-Ade Mesylate (100 μM; 30 min) attenuates the effects of relaxin on mechanical activity and prevents relaxin-induced hyperpolarization, thereby participating in the regulation of relaxin on ileal smooth muscle activity in female CD1 Swiss mice. 9-CP-Ade Mesylate (100 μM; 6 h) promotes restoration of the keratinocyte permeability barrier by inhibiting cAMP synthesis in male hairless mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

9 CP Ade Mesylate, 9CPAde Mesylate, 9-CP-Ade Mesylate, 9-Cyclopentyladenine monomethanesulfonate, adenylate cyclase

Compound Identifiers

PubChem CID

6604076