(±)8(9)-EET

SKU: orb3174705

Description

(±)8(9)-EET is a principal metabolite of Arachidonic Acid formed via the cytochrome P450 epoxygenase pathway. It serves as an effective substrate for COX-1 and COX-2. In HEK293 cells, (±)8(9)-EET activates PPARα and suppresses IL-1β-induced NF-κB activity through both PPARα-dependent and independent mechanisms. The (8S,9R)-isomer ((8S,9R)-EET) induces vasoconstriction, reducing renal plasma flow and glomerular filtration rate.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 184488-44-6
• MW: 320.47
• Formula: C₂₀H₃₂O₃
• SMILES: C(/C=C\C/C=C\CCCCC)C1C(C/C=C\CCCC(O)=O)O1
• Target: NF-κB,PPAR,COX,Drug Metabolite

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,PPAR,COX,Drug Metabolite