8-Deoxygartanin

SKU: orb1297477

Description

8-Deoxygartanin

Research Area

Infectious Disease & Virology, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 33390-41-9
• MW: 380.43
• Purity: 99.88%
• Formula: C₂₃H₂₄O₅
• SMILES: CC(C)=CCc1c(O)c(CC=C(C)C)c2oc3c(O)cccc3c(=O)c2c1O
• Target: NF-κB,Beta Amyloid,Parasite
• Solubility: DMSO:55 mg/mL (144.57 mM)

Bioactivity

• Target IC50:
  p65:11.3 μM (IC50)
• In Vitro:
  The present study investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of G. mangostana extract and its chemical constituents using Ellman's colorimetric method. Cholinesterase inhibitory-guided approach led to identification of six bioactive prenylated xanthones showing moderate to potent cholinesterases inhibition with IC50 values of lower than 20.5 μM. The most potent inhibitor of AChE was garcinone C while γ-mangostin was the most potent inhibitor of BChE with IC50 values of 1.24 and 1.78 μM, respectively. Among the xanthones, mangostanol, 3-isomangostin, garcinone C and α±-mangostin are AChE selective inhibitors, 8-Deoxygartanin is a BChE selective inhibitor while γ-mangostin is a dual inhibitor. Preliminary structure-activity relationship suggests the importance of the C-8 prenyl and C-7 hydroxy groups for good AChE and BChE inhibitory activities. The enzyme kinetic studies indicate that both α±-mangostin and garcinone C are mixed-mode inhibitors, while γ-mangostin is a non-competitive inhibitor of AChE. In contrast, both γ-mangostin and garcinone C are uncompetitive inhibitors, while α±-mangostin is a mixed-mode inhibitor of BChE

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Parasite, p65, Nuclear factor-κB, Nuclear factor-kappaB, NFkB, NF-kB, NF-κB, NFκB, Inhibitor, BetaAmyloid, Beta Amyloid, 8 Deoxygartanin, 8Deoxygartanin, 8-Deoxygartanin, b Amyloid, bAmyloid, β Amyloid, βAmyloid

Compound Identifiers

PubChem CID

392450