8-bromo NAD+ sodium

SKU: orb2276832

Description

8-Bromo NAD+ is a prodrug converted by CD38 into the active cADPR antagonist 8-bromo cADPR. It inhibits fMLP-induced calcium mobilization and chemotaxis in neutrophils (1 mM) and, at 100 µM, suppresses LPS-triggered nitrite production and cytokine secretion in microglial cells, useful for studying calcium signaling and inflammation in vitro.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2022926-16-3
• MW: 764.30
• Formula: C₂₁H₂₅BrN₇O₁₄P₂.Na
• SMILES: O[C@H]([C@@H]([C@H](O1)COP([O-])(OP([O-])(OC[C@H]([C@H]([C@H]2O)O)O[C@H]2[N+]3=CC(C(N)=O)=CC=C3)=O)=O)O)[C@@H]1N4C5=NC=NC(N)=C5N=C4Br.[Na+]
• Target: Others,Calcium Channel

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168445927