8-Azaadenosine

SKU: orb1298360

Description

8-Azaadenosine is a potent small molecule inhibitor of ADAR1-mediated adenosine-to-inosine RNA editing. It effectively suppresses key oncogenic phenotypes in thyroid cancer models, including proliferation, 3D spheroid growth, and cell invasion, as demonstrated in vitro. This compound is a valuable research tool for studying RNA editing in cancer biology and metastasis.

Research Area

Metabolism Research

Key Properties

• CAS Number: 10299-44-2
• MW: 268.23
• Purity: 99.63% (May vary between batches)
• Formula: C₉H₁₂N₆O₄
• SMILES: Nc1ncnc2n(nnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
• Target: Adenosine Deaminase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.64 mM);DMSO:245 mg/mL (913.4 mM)

Bioactivity

• In Vitro:
  8-azaadenosine (8-aza-AR) was a potent inhibitor of purine synthesis de novo, but 8-aza-HR, at concentrations much higher than the inhibitory concentration of 8-aza-AR, did not inhibit this process. In H. Ep. 2 cells, 8-aza-HR blocked the conversion of orotic acid to uridine nucleotides and caused an accumulation of orotidine. This inhibition of pyrimidine biosynthesis apparently does not contribute significantly to the cytotoxicity of 8-aza-HR because uridine provided no degree of reversal of its inhibition of the growth of cell cultures.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

editing, Cal62, ADAR1, Adenosinedeaminase, 8Azaadenosine, 8-Azaadenosine, 8 Azaadenosine, Adenosine Deaminase, Adenosine deaminase, inhibit, invasion, LIN28B, migration, Inhibitor, proliferation, thyroid, TPC1, RNA

Compound Identifiers

PubChem CID

96410