7BIO

SKU: orb1306122

Description

7-Bromoindirubin-3'-oxime (7BIO) is a cell death inducer that operates independently of caspases and apoptosis. It functions as a multi-kinase inhibitor, targeting FLT3, DYRK1A, DYRK2, Aurora B, and Aurora C. This compound is utilized in vitro to study non-apoptotic cell death mechanisms in cancer research.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 916440-85-2
• MW: 356.17
• Purity: 99.77% (May vary between batches)
• Formula: C₁₆H₁₀BrN₃O₂
• SMILES: O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2c1cccc2Br
• Target: CDK,GSK-3,DYRK,Aurora Kinase,FLT
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.62 mM);Ethanol:Soluble;DMSO:36.67 mg/mL (102.96 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tau hyper-phosphorylation, synaptic impairments, Glycogen synthase kinase-3, Glycogen synthase kinase 3, FLT3, GSK-3, GSK3β, Inhibitor, neuroinflammation, inhibit, activation of astrocytes and microglia, 7BIO, AuroraKinase, Aurora Kinase, Aurora B, Aurora C, Aβ oligomer, DYRK1A, DYRK2, Cyclin dependent kinase, cognitive impairment, CDK5, CDK

Compound Identifiers

PubChem CID

135423792