7,4'-Dihydroxyflavone

SKU: orb1297492

Description

This small molecule flavonoid serves as a nod gene inducer in Rhizobium meliloti and exhibits COX-2 inhibitory activity. It is a useful research tool for studying plant-microbe symbiosis and inflammation pathways in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2196-14-7
• MW: 254.24
• Purity: 99.39% (May vary between batches)
• Formula: C₁₅H₁₀O₄
• SMILES: Oc1ccc(cc1)-c1cc(=O)c2ccc(O)cc2o1
• Target: HDAC|||COX|||CCR|||NF-κB|||NOD
• Solubility: DMSO:250 mg/mL (983.32 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (19.67 mM)

Bioactivity

• Target IC50:
  NCI-H292 cells:1.4 μM (NCI-H292 human airway epithelial cell) (IC50)
• In Vitro:
  Root exudate from 3-day-old alfalfa seedlings was purified and then assayed for biological activity with a nodABC-lacZ fusion in R. meliloti. Indentities of major nod inducers were established by spectroscopic analyses (ultraviolet/visible, proton nuclear magnetic resonance, and mass spectroscopy) and comparison with authentic standards. Major nod inducers, which were identified as 4',7-Dihydroxyflavone, 4'-7-dihydroxyflavanone, and 4,4'-dihydroxy-2'-methoxychalcone, were released from seedling roots at 54, 22, and 20 picomole.plant(-1).day(-1), respectively. Luteolin was not found in these root exudates.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4',7-Dihydroxyflavone, 7,4' Dihydroxyflavone, 7,4'Dihydroxyflavone, 7,4'-Dihydroxyflavone, CCR, COX, CC chemokine receptor, inhibit, Inhibitor, NF-κB, NF-kB, NFκB, NFkB, NOD1, Nuclear factor-κB, Nuclear factor-kappaB, HDAC2

Compound Identifiers

PubChem CID

5282073