7-Methoxyflavone

SKU: orb1299394

Description

This small molecule, 7-Methoxyflavone, is a natural compound isolated from Zornia brasiliensis. It exhibits antinociceptive properties, making it a useful research tool for studying pain mechanisms in both in vitro and in vivo models of nociception.

Research Area

Metabolism Research

Key Properties

• CAS Number: 22395-22-8
• MW: 252.2647
• Purity: 99.51% (May vary between batches)
• Formula: C₁₆H₁₂O₃
• SMILES: COC1=CC=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1
• Target: Cytochromes P450,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.93 mM);DMSO:25 mg/mL (99.1 mM)

Bioactivity

• In Vivo:
  The antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inflammatory, inhibit, paw-licking time, 7Methoxyflavone, 7-Methoxyflavone, 7 Methoxyflavone, peripheral antinociceptive

Compound Identifiers

PubChem CID

466268