7-Hydroxycarbostyril

SKU: orb1940425

Description

7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate.(In Vitro): VPC-80051 as the first small molecule inhibitor of hnRNP A1 splicing activity discovered to date by using a computer-aided drug discovery approach. The inhibitor was developed to target the RNA-binding domain (RBD) of hnRNP A1. Further experimental evaluation demonstrated that VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1 RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms.

Key Properties

• CAS Number: 70500-72-0
• MW: 161.16
• Purity: >98% (HPLC)
• Formula: C₉H₇NO₂
• SMILES: Oc1ccc2ccc(O)nc2c1
• Target: TRPA1

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,4-Dihydro-7-hydroxycarbostyril

Quick Database Links

Gene Symbol

TRPA1