7-FluorotryptaMine HCl

SKU: orb1819003

Description

7-Fluorotryptamine HCl is a selective GPRC5A agonist that promotes β-arrestin recruitment via this receptor. This compound serves as a valuable research tool for investigating GPRC5A signaling in the contexts of immunology and oncology, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 159730-09-3
• MW: 214.67
• Purity: 98.06% (May vary between batches)
• Formula: C₁₀H₁₂ClFN₂
• SMILES: Cl.FC1=CC=CC=2C(=CNC12)CCN
• Target: GPCR,Arrestin
• Solubility: DMSO:21.47 mg/mL (100.01 mM)

Bioactivity

• In Vitro:
  In the PRESTO-Tango assay, 7-FluorotryptaMine HCl (100 μM) hydrochloride induces GPRC5A recruitment of β-arrestin. Co-treatment with 7-FluorotryptaMine HCl (50 μM, 8 h) and TNFα downregulates TNFα-induced genes (e.g., IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells . 7-FluorotryptaMine HCl (0-100 μM, 16 h) is not toxic to mammalian cells (HTLA, HT-29 cells).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7FluorotryptaMineHCl, 7-FluorotryptaMine HCl, GPRC5A

Compound Identifiers

PubChem CID

53487481