(6R)-FR054

SKU: orb1298511

Description

(6R)-FR054 is a potent and selective small molecule inhibitor of PGM3, a key enzyme in the Hexosamine Biosynthetic Pathway (HBP). It demonstrates significant anti-proliferative activity against breast cancer cells in vitro and has shown efficacy in reducing tumor growth in vivo models, making it a valuable chemical probe for oncology and metabolic pathway research.

Research Area

Cell Biology

Key Properties

• CAS Number: 10378-06-0
• MW: 329.3
• Purity: 99.83% (May vary between batches)
• Formula: C₁₄H₁₉NO₈
• SMILES: [H][C@@]12OC(C)=N[C@]1([H])[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2
• Target: Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.15 mM);DMSO:100 mg/mL (303.67 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast, Apoptosis, cancer, (6R) FR054, (6R)FR054, (6R)-FR054, (6R)-FR-054, ERS, FR054, FR-054, FR 054, Inhibitor, inhibit, PGM3, TNBC

Compound Identifiers

PubChem CID

11278902