6-Thioguanine

SKU: orb1304554

Description

6-Thioguanine

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 154-42-7
• MW: 167.19
• Purity: 99.26%
• Formula: C₅H₅N₅S
• SMILES: NC1=NC2=C(N=CN2)C(S)=N1
• Target: SARS-CoV,DNA Methyltransferase,DUB,Apoptosis,Endogenous Metabolite,Autophagy
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:62.5 mg/mL (373.83 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.98 mM)

Bioactivity

• Target IC50:
  Plpro:25 μM|USP2:40 μM
• In Vivo:
  6-Thioguanine is integrated into DNA, differing from typical DNA bases as it serves as a potent UVA chromophore with a peak absorbance at 342 nm. Its incorporation alters topoisomerase II-induced DNA cleavage both in the presence and absence of etoposide. Additionally, 6-Thioguanine induces similar apoptotic responses in mismatch repair-proficient and -deficient HCT116 and HeLa cells.
• In Vitro:
  6-Thioguanine selectively kills BRCA2-deficient tumors in xenograft models as effectively as PARP inhibitors. It eradicates cells and tumors that have developed resistance to PARP inhibitors or cisplatin through genetic reversal via the BRCA2 gene. Additionally, 6-Thioguanine is effective in eliminating PARP inhibitor-resistant tumors with BRCA1 deficiencies.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, EndogenousMetabolite, Inhibitor, Endogenous Metabolite, DUBs, DNMT1, DNMTs, DNAMethyltransferase, DNA MTases, DNA methyltransferase (DNMT), DNA Methyltransferase, Deubiquitinase, Apoptosis, Autophagy, 2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol, 6 Thioguanine, 6-TG, 6Thioguanine, 6-Thioguanine, Thioguanine, SARS-CoV, SARS coronavirus, SARSCoV, USP2

Compound Identifiers

PubChem CID

2723601