6-O-Isobutyrylbritannilactone

SKU: orb1981884

Description

6-O-Isobutyrylbritannilactone is a sesquiterpene natural product that inhibits melanogenesis. It suppresses IBMX-induced pigmentation in B16F10 melanoma cells by modulating ERK, CREB, and PI3K/AKT signaling pathways and reduces pigmentation in zebrafish embryo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1259933-02-2
• MW: 336.42
• Formula: C₁₉H₂₈O₅
• SMILES: O(C(C(C)C)=O)[C@H]1[C@]2([C@@](CC(C)=C1[C@H](CCCO)C)(OC(=O)C2=C)[H])[H]
• Target: Others

Bioactivity

• In Vivo:
  6-O-Isobutyrylbritannilactone (10-100 μM, 48 hours) can significantly reduce pigmentation in zebrafish embryos .
• In Vitro:
  6-O-Isobutyrylbritannilactone (5-100 μM, 48 hours) exhibited cytotoxicity against IBMX-stimulated B16F10 cells . 6-O-Isobutyrylbritannilactone (5-30 μM, 12 hours) dose-dependently inhibited the mRNA expression levels of whitening-related genes in IBMX-stimulated B16F10 cells . 6-O-Isobutyrylbritannilactone (20 μM, 1-9 hours) time-dependently suppressed the phosphorylation of ERK, AKT, and CREB .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

50917934