6-Methoxydihydrosanguinarine

SKU: orb1298684

Description

6-Methoxydihydrosanguinarine

Key Properties

• CAS Number: 72401-54-8
• MW: 363.36
• Purity: 99.32% (May vary between batches)
• Formula: C₂₁H₁₇NO₅
• SMILES: COC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc3OCOc3c12
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.08 mM);DMSO:50 mg/mL (137.6 mM)

Bioactivity

• Target IC50:
  MCF-7 cells:0.61 μM (IC50)|SF-268 cells:0.54 μM (IC50)
• In Vivo:
  6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent. 6ME inhibits the growth of HepG2 cells in a concentration- and time-dependent manner (IC50=3.8+/-0.2 microM following 6 h incubation). Treatment of HepG2 cells with 6ME resulted in the release of mitochondrial cytochrome c followed by the activation of caspase proteases, and subsequent proteolytic cleavage of poly(ADP-ribose) polymerase. 6ME increased the expression of p53 and bax and decreased the expression of bcl-2. The cytotoxic effect of 6ME is mediated by the time-dependent generation of reactive oxygen species. Preincubation of HepG2 cells with vitamin C decreased the expression of p53 and bax and inhibited the release of cytochrome c, activation of downstream caspase and the cleavage of poly(ADP-ribose) polymerase, thus inhibiting the apoptosis inducing effect of 6ME
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, 6 Methoxydihydrosanguinarine, 6Methoxydihydrosanguinarine, 6-Methoxydihydrosanguinarine, MCF-7, Inhibitor, inhibit, lkaloid, SF-268

Compound Identifiers

PubChem CID

14847270