6-Hydroxy-DOPA

SKU: orb1305230

Description

6-Hydroxy-DOPA is a small molecule that acts as an allosteric RAD52 inhibitor and suppresses APE1 activity. It demonstrates anti-proliferative effects in BRCA-deficient cell cultures, making it a candidate for studying synthetic lethality and DNA repair pathways in oncology research.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 21373-30-8
• MW: 213.19
• Purity: 96.59% (May vary between batches)
• Formula: C₉H₁₁NO₅
• SMILES: C(C(C(O)=O)N)C1=C(O)C=C(O)C(O)=C1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:2.14 mg/mL (10.04 mM)

Bioactivity

• In Vivo:
  Importantly, we show that 6-OH-dopa selectively inhibits the proliferation of BRCA-deficient cancer cells, including those obtained from leukemia patients. Taken together, these data demonstrate small-molecule disruption of RAD52 rings as a promising mechanism for precision medicine in BRCA-deficient cancers.
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• In Vitro:
  We identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor of the RAD52 ssDNA binding domain. For example, we find that multiple small molecules bind to and completely transform RAD52 undecamer rings into dimers, which abolishes the ssDNA binding channel observed in crystal structures. 6-OH-Dopa also disrupts RAD52 heptamer and undecamer ring superstructures, and suppresses RAD52 recruitment and recombination activity in cells with negligible effects on other double-strand break repair pathways.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, effective, Inhibitor, HCC1937, cancer, 6 Hydroxy DOPA, 6HydroxyDOPA, 6-Hydroxy-DOPA, 6-Hydroxy-DL-DOPA, allosteric, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, U20S, selective, RAD52 ssDNA, ssDNA, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

107794