[6]-Gingerol

SKU: orb1304232

Description

[6]-Gingerol

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 23513-14-6
• MW: 294.39
• Purity: 99.66%
• Formula: C₁₇H₂₆O₄
• SMILES: CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1
• Target: AMPK,Apoptosis
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;DMSO:50 mg/mL (169.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.79 mM)

Bioactivity

• In Vivo:
  In animal studies, -gingerol effectively mitigates DSS-induced colitis symptoms by reversing body weight loss, decreasing intestinal bleeding, and preventing colon shortening. It also inhibit the DSS-induced increase in proinflammatory cytokines (IL-1β, TNFα, and IL-12.
• In Vitro:
  -Gingerol selectively inhibits proliferation and induces apoptosis in colon cancer cells while sparing normal colon cells. It modulates cell signaling by down-regulating phorbol myristate acetate-induced phosphorylation of ERK1/2 and JNK MAP kinases and reducing AP-1 transcription factor activation, with minimal impact on p38 MAP kinase phosphorylation and NF-kappa B activatio. Moreover, -gingerol enhances intestinal barrier function and diminishes proinflammatory responses in DSS-treated Caco-2 monolayers, partly by activating AMP. Additionally, it significantly reduces osteosarcoma cell viability in a dose-dependent manner, increases sub-G1 cell cycle arrest, and activates caspase cascades while adjusting Bcl2 and Bax protein level.
• Cell Research:
  -gingerol stock (20 mg/mL) is prepared in ethanol an the working concentration are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, × 0^3 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with -gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V stainin.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

gingerol, AMPK, Apoptosis, 6-Gingerol, (S)-(+)-[6]Gingerol, [6]Gingerol, [6]-Gingerol, [6] Gingerol

Compound Identifiers

PubChem CID

442793