6-Diazo-5-oxo-L-nor-Leucine

SKU: orb1685388

Description

6-Diazo-5-oxo-L-norleucine (DON) is a glutaminase inhibitor (Ki: ~6 µM) with antineoplastic properties, originally isolated from Streptomyces. It is widely used in cancer metabolism research to study glutamine dependency in vitro and has been evaluated in historical clinical trials for its antitumor effects in vivo.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 157-03-9
• MW: 171.15
• Purity: 99.56% (May vary between batches)
• Formula: C₆H₉N₃O₃
• SMILES: N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
• Target: Glutaminase,Influenza Virus,Antibiotic,Antibacterial
• Solubility: H2O:12.5 mg/mL (73.04 mM);DMSO:7 mg/mL (40.9 mM)

Bioactivity

• Target IC50:
  Glutaminases:6 μM (Ki)|GLS1:~1 mM

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6 Diazo 5 oxo L nor Leucine, 6Diazo5oxoLnorLeucine, 6-Diazo-5-oxo-L-nor-Leucine, Antibiotic, Bacterial, Diazooxonorleucine, DON, Glutaminase, Inhibitor, L-6-Diazo-5-oxonorleucine, inhibit, Influenza Virus, InfluenzaVirus

Compound Identifiers

PubChem CID

9087