6-Demethoxytangeretin

SKU: orb1299173

Description

6-Demethoxytangeretin is a polymethoxylated flavonoid obtained from Citrus depressa. It serves as a research tool for investigating anti-inflammatory and neuroprotective mechanisms in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 6601-66-7
• MW: 342.34
• Purity: 99.89% (May vary between batches)
• Formula: C₁₉H₁₈O₆
• SMILES: COc1ccc(cc1)-c1cc(=O)c2c(OC)cc(OC)c(OC)c2o1
• Target: Interleukin,Akt,MAPK,JAK,STAT,p38 MAPK,ERK,ALK,JNK
• Solubility: DMSO:3.43 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via ALK and MAPK pathways . 6-Demethoxytangeretin facilitates the Cre-mediated transcription associated with learning and memory in cultured hippocampal neurons .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cluster of differentiation 246, CD246, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, 6 Demethoxytangeretin, ALK, ALK tyrosine kinase receptor, 6Demethoxytangeretin, 6-Demethoxytangeretin, inhibit, Inhibitor, MAPK

Compound Identifiers

PubChem CID

629964