6-Dehydrogingerdione

SKU: orb1684921

Description

6-Dehydrogingerdione enhances TRAIL-induced apoptosis in Hep G2 cells via ROS-mediated DR5 upregulation and p53 activation. This compound is a useful research tool for studying p53-dependent apoptotic pathways and TRAIL sensitization mechanisms in cancer cell models, including hepatoblastoma, in vitro.

Research Area

Cell Biology

Key Properties

• CAS Number: 76060-35-0
• MW: 290.35
• Purity: 96.98%
• Formula: C₁₇H₂₂O₄
• SMILES: C(=C/C(CC(CCCCC)=O)=O)\C1=CC(OC)=C(O)C=C1
• Target: Prostaglandin Receptor,NOS,Apoptosis,COX
• Solubility: DMSO:80 mg/mL (275.53 mM)

Bioactivity

• In Vitro:
  6-Dehydrogingerdione (0- 50 μM, 24 hours) induced apoptosis in Hep G2 cells in a dose-dependent manner.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

6Dehydrogingerdione, 6-Dehydrogingerdione, 6 Dehydrogingerdione, 1-Dehydro-6-gingerdione, COX, NOS, PGE, Prostaglandin Receptor

Compound Identifiers

PubChem CID

9796015