6-Chloromelatonin

SKU: orb1704721

Description

6-Chloromelatonin is a metabolically stable melatonin receptor agonist with high affinity for MT2 receptors. It is utilized in sleep and depression research to study receptor function and neurotransmitter release, such as dopamine, in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 63762-74-3
• MW: 266.72
• Purity: 99.36% (May vary between batches)
• Formula: C₁₃H₁₅ClN₂O₂
• SMILES: C(CNC(C)=O)C=1C=2C(=CC(Cl)=C(OC)C2)NC1
• Target: Melatonin Receptor,Dopamine Receptor
• Solubility: DMSO:90 mg/mL (337.43 mM)

Bioactivity

• Target IC50:
  MT1:8.9 (pKi)|MT2:9.1 (pKi)
• In Vivo:
  6-Chloromelatonin (0.5 mg/kg; injection; rats) on the day after the phase shift has markedly higher excretion rates of 6-Sulphatoxymelatonin compared with controls.
• In Vitro:
  6-Chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 h) inhibits forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells in a dose-dependent manner but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels. 6-Chloromelatonin competes for [3H]-melatonin binding sites in human platelet (Ki=11.4 nM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopamine, Dopamine Receptor, DopamineReceptor, 6 Chloromelatonin, 6Chloromelatonin, 6-Chloromelatonin, Melatonin Receptor, MelatoninReceptor

Compound Identifiers

PubChem CID

1858