6-Bromo-2-hydroxy-3-methoxybenzaldehyde

SKU: orb1299781

Description

6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is a potent small molecule inhibitor of the endoplasmic reticulum stress sensor IRE1α, exhibiting an IC50 of 0.08 μM. It is a valuable research tool for studying the unfolded protein response (UPR) in cellular models of neurodegeneration, cancer, and metabolic diseases.

Research Area

Cell Biology

Key Properties

• CAS Number: 20035-41-0
• MW: 231.04
• Purity: 99.82% (May vary between batches)
• Formula: C₈H₇BrO₃
• SMILES: C(=O)C1=C(O)C(OC)=CC=C1Br
• Target: IRE1
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.66 mM);DMSO:50 mg/mL (216.41 mM)

Bioactivity

• Target IC50:
  IRE1α:0.08 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Inositol requiring enzyme 1, inhibit, NSC 95682, IRE1, IRE1α, NSC95682, NSC-95682, 6 Bromo 2 hydroxy 3 methoxybenzaldehyde, 6Bromo2hydroxy3methoxybenzaldehyde, 6-Bromo-2-hydroxy-3-methoxybenzaldehyde

Compound Identifiers

PubChem CID

262237