6-Biopterin

SKU: orb1299675

Description

L-Biopterin is a naturally occurring cofactor essential for nitric oxide synthase (NOS) activity. It is widely used in biochemical research to study NOS function and nitric oxide signaling pathways in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 22150-76-1
• MW: 237.22
• Purity: 99.91% (May vary between batches)
• Formula: C₉H₁₁N₅O₃
• SMILES: C[C@H](O)[C@H](O)c1cnc2nc(N)nc(O)c2n1
• Target: NOD,Endogenous Metabolite,NO Synthase
• Solubility: DMSO:6 mg/mL (25.29 mM)

Bioactivity

• In Vitro:
  The oxidized cofactor 6-biopterin (0.2 x 10(-6) M) is extremely cytotoxic to human melanocytes under in vitro conditions. Consequently, its reduction to 6-BH4 via q-BH2 is essential to melanocyte viability.human thioredoxin reductase has the capacity to reduce 6-biopterin to q-BH2 where further reduction to 6-BH4 follows via dihydropteridine reductase or reduced glutathione.

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, Inhibitor, L-Biopterin, NOSynthase, NOS, inhibit, Nitric oxide synthases, NO synthesis, NO Synthase, 6Biopterin, 6-Biopterin, 6 Biopterin

Compound Identifiers

PubChem CID

135403659