5(S),6(R)-DiHETE is a nonenzymatic hydrolysis derivative of leukotriene A4 (LTA4), also formed via mouse liver cytosolic epoxide hydrolase. This lipid mediator acts as a weak LTD4 receptor agonist, inducing guinea pig ileum contraction (ED50 ~1.3 µM), and is used in research on eicosanoid signaling and inflammation.