5,7,8-Trimethoxyflavone

SKU: orb1684370

Description

5,7,8-Trimethoxyflavone, a trimethyl ether derivative of norwogonin isolated from Andrographis paniculata, acts as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. This small molecule is utilized in biochemical research for studying inflammatory pathways and has demonstrated activity in both in vitro cellular assays and in vivo experimental models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 23050-38-6
• MW: 312.32
• Purity: 99.89% (May vary between batches)
• Formula: C₁₈H₁₆O₅
• SMILES: O=C1C=C(OC=2C(OC)=C(OC)C=C(OC)C12)C=3C=CC=CC3
• Target: NO Synthase
• Solubility: DMSO:30 mg/mL (96.06 mM)

Bioactivity

• In Vitro:
  In RAW 264.7 macrophages, 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) decreases NO production in a dose-dependent manner at concentrations of 8, 16, 32, and 64 μM after 24 hours of treatment. The compound does not alter lipopolysaccharide (LPS)-induced (100 ng/mL) cell viability .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5,7,8 Trimethoxyflavone, 5,7,8Trimethoxyflavone, 5,7,8-Trimethoxyflavone, Norwogonin 5,7,8-trimethyl ether, NOSynthase, NO, NO Synthase

Compound Identifiers

PubChem CID

14756218