5,​7,​4'-​Trimethoxyflavone

SKU: orb1299058

Description

5,7,4'-Trimethoxyflavone is a bioactive flavonoid purified from the Thai medicinal plant Kaempferia parviflora. It serves as a key research compound for investigating anti-inflammatory and anticancer mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 5631-70-9
• MW: 312.32
• Purity: 97.53% (May vary between batches)
• Formula: C₁₈H₁₆O₅
• SMILES: COc1ccc(cc1)-c1cc(=O)c2c(OC)cc(OC)cc2o1
• Target: Caspase|||Apoptosis|||PARP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.4 mM);DMSO:22.5 mg/mL (72.04 mM)

Bioactivity

• In Vitro:
  5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of PARP protein. 5,7,4'-Trimethoxyflavone is significantly effective at inhibiting the proliferation of SNU-16 human gastric cancer cells in a concentration-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caspase-3, Caspase, Apoptosis, 5,7,4'-Trimethoxyflavone, 5,​7,​4' ​Trimethoxyflavone, 5,​7,​4'​Trimethoxyflavone, 5,?7,?4'-?Trimethoxyflavone, 4',5,7-Trimethoxyflavone, Inhibitor, Endogenous Metabolite, PARP, inhibit, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

79730