5,6-trans-Vitamin D3

SKU: orb1694551

Description

5,6-trans-Vitamin D3 is a photoisomer of cholecalciferol (Vitamin D3) formed upon skin exposure to UV light. This analog is used in biochemical research to study vitamin D metabolism, receptor binding, and the effects of stereochemistry in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 22350-41-0
• MW: 384.64
• Purity: 98.23%
• Formula: C₂₇H₄₄O
• SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1/C[C@@H](O)CCC1=C
• Target: Vitamin
• Solubility: Ethyl Acetate:20 mg/mL (52 mM);DMSO:1 mg/mL (2.6 mM);Ethanol:30 mg/mL (78 mM);DMF:10 mg/mL (26 mM)

Bioactivity

• In Vitro:
  The dissociation constants of vitamin D receptor (VDR) for 25-hydroxytachysterol3, 25-hydroxy-5,6-trans-vitamin D3, and 5,6-trans-vitamin D3 were 22, 58, and 560 nM, respectively. The dissociation constants for 7-dehydrocholesterol, tachysterol, and lumisterol were greater than 20 microM. In conclusion, vitamin D3, its photoisomers and the photoisomers of previtamin D3 have antiproliferative activity in cultured human keratinocytes..

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5,6-trans-Cholecalciferol, 5,6-trans-Colecalciferol, 5,6transVitamin D3, 5,6-trans-Vitamin D3, 5,6-trans-Vitamin D-3, 5,6 trans Vitamin D3, Cholecalciferol EP Impurity A, VD3

Compound Identifiers

PubChem CID

5283711