5,6-Dihydroxyindole

SKU: orb1710547

Description

5,6-Dihydroxyindole is a melanin precursor with broad-spectrum antimicrobial activity against bacteria, viruses, fungi, and parasites. Its cytotoxic properties are utilized in research on pigment biology and in vitro studies of pathogen inhibition.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 3131-52-0
• MW: 149.147
• Purity: 99.48% (May vary between batches)
• Formula: C₈H₇NO₂
• SMILES: OC1=CC2=C(C=C1O)C=CN2
• Target: Antifungal,Endogenous Metabolite,Parasite,Antibacterial
• Solubility: DMSO:1.5 mg/mL (10.06 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.7 mM)

Bioactivity

• In Vitro:
  5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) reduces OD492 values in a dose-dependent manner. Pre-treating Sf9 cells with 1.0 mM 5,6-Dihydroxyindole for 4 hours results in 97% mortality, with LC50 values of 20.3 μM in buffer and 131.8 μM in culture medium. Pre-incubation of a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours nearly completely inhibits recombinant protein production. The compound also shows activity against lambda bacteriophage and wasp eggs (Microplitis demolitor), with LC50 values of 5.6 μM and 111.0 μM, respectively. Both 5,6-Dihydroxyindole and its spontaneous oxidation products are effective against viruses and parasitic wasps .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dopamine lutine, 5,6-Dihydroxyindole, EndogenousMetabolite, Endogenous Metabolite, Human Endogenous Metabolite

Compound Identifiers

PubChem CID

114683