5α-Tetrahydrocorticosterone

SKU: orb3136105

Description

5α-Tetrahydrocorticosterone (5α-HB) is an endogenous steroid that acts as an agonist of the glucocorticoid receptor (GR) and a metabolite of corticosterone. It serves as an effective topical anti-inflammatory agent in vivo. In rat liver cells, it decreases the binding of metabolites to the glucocorticoid receptor-corticosterone and its 5α-reduced metabolites, with a Kd value of 268 nM. 5α-Tetrahydrocorticosterone is applicable in research on inflammatory skin diseases.

Key Properties

• CAS Number: 600-63-5
• MW: 350.49
• Formula: C₂₁H₃₄O₄
• SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(C[C@@H]3O)[C@@H](C(CO)=O)CC4)[H])(CC[C@]1(C[C@H](O)CC2)[H])[H])[H]
• Target: Drug Metabolite,Glucocorticoid Receptor,Endogenous Metabolite

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Drug Metabolite,Glucocorticoid Receptor,Endogenous Metabolite