5-Ph-IAA

SKU: orb1218658

Description

5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.

Key Properties

• CAS Number: 168649-23-8
• MW: 251.28
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₃NO₂
• SMILES: C1=CC=C(C=C1)C2=CC3=C(C=C2)NC=C3CC(=O)O
• Target: Others
• Solubility: DMSO:125 mg/mL (497.45 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Balb/c-nu female mice (7 weeks old; 16–20 g) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells. Dosage: 0 mg/kg, 1 mg/kg, 3 mg/kg and 10 mg/kg. Administration: Intraperitoneally injection; every day; 7 days. Result: Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts.
• In Vitro:
  Western blot analysis. Cell line: HCT116 cells. Concentration: 1 μM. Incubation time: 6 hours. Result: Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

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