5'-ODMT cEt m5U Phosphoramidite (Amidite)

SKU: orb2281226

Description

This phosphoramidite reagent, featuring a constrained ethyl (cEt) locked nucleic acid (LNA) backbone and a 5-methyluridine (m5U) base, is designed for oligonucleotide synthesis. Its resulting antisense oligonucleotides demonstrate potent gene silencing activity and a favorable safety profile in both cellular and animal studies, supporting therapeutic discovery research.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1197033-22-9
• MW: 786.85
• Formula: C₄₂H₅₁N₄O₉P
• SMILES: [H][C@]12O[C@@H](C)[C@](COC(c3ccccc3)(c3ccc(OC)cc3)c3ccc(OC)cc3)(O[C@H]1n1cc(C)c(=O)[nH]c1=O)[C@H]2OP(OCCC#N)N(C(C)C)C(C)C
• Target: Nucleoside Antimetabolite/Analog,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

45139656