5-(N,N-Hexamethylene)-amiloride

SKU: orb2893603

Description

5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1428-95-1
• MW: 311.77
• Purity: 85.48% (May vary between batches)
• Formula: C₁₂H₁₈ClN₇O
• SMILES: NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1
• Target: TRP/TRPV Channel,Apoptosis,P2X Receptor,Sodium Channel,HIV Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

1794