5-Hydroxymethyldeoxyuridine

SKU: orb1217951

Description

5-Hydroxymethyldeoxyuridine is an analog of nucleoside that has anticancer and antiviral activities. It suppresses the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).

Key Properties

• CAS Number: 5116-24-5
• MW: 258.23
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₄N₂O₆
• SMILES: OC[C@H]([C@H](C1)O)O[C@H]1N(C=C(CO)C(N1)=O)C1=O
• Target: others
• Solubility: DMSO:Soluble

Bioactivity

• In Vivo:
  5-Hydroxymethyl-2'-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) increases the survival of DBA/2 mice carrying L1210 leukemia.
• In Vitro:
  5-Hydroxymethyl-2'-deoxyuridine (0-10 μM) inhibits the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells with ED50 values of 8.5 and 4 μM, respectively. 5-Hydroxymethyl-2'-deoxyuridine inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase with a Ki value of 3.5 μM.5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM.5-Hydroxymethyl-2'-deoxyuridine (10-100 μM) shows dose-dependent toxicity against a human acute promyelocytic leukemia cell line.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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others