5-Hydroxydecanoic acid

SKU: orb2567335

Description

5-Hydroxydecanoic acid is a selective mitochondrial KATP channel blocker with an IC50 of approximately 30 µM. It serves as a substrate for outer membrane acyl-CoA synthetase and exhibits antioxidant properties, making it a useful tool for investigating cardiac ischemia, diabetes, and mitochondrial function in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 624-00-0
• MW: 188.26
• Purity: 99.84% (May vary between batches)
• Formula: C₁₀H₂₀O₃
• SMILES: O=C(O)CCCC(O)CCCCC
• Target: ATPase,Potassium Channel
• Solubility: H2O:8 mg/mL (42.49 mM);DMSO:11.7 mg/mL (62.15 mM)

Bioactivity

• In Vivo:
  5-Hydroxydecanoate (100 μM) treatment abolishes the effects of ischemic preconditioning (IPC) on the contractile recovery and does not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats.
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• In Vitro:
  5-Hydroxydecanoate (5-HD) treatment abolishs the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate blocks the inhibitory effect of PHC on Ca2+ overload and ROS production. 5-Hydroxydecanoate promotes the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate attenuats the anti-apoptotic effect of PHC. PHC treatment shows remarkably decreases levels of Bax and cleaved caspase-3, and increases levels of Bcl-2. 5-Hydroxydecanoate pretreatment reverses the effects of PHC on their expression levels. 5-Hydroxydecanoate blocks the effects of PHC on KATP channels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sodium 5-hydroxydecanoate, ATP-sensitive K+ channels

Compound Identifiers

PubChem CID

1825