5α-Hydroxy-6-keto cholesterol

SKU: orb1694755

Description

5α-Hydroxy-6-keto cholesterol is a cytotoxic β-epoxide oxysterol generated from ozone-exposed human bronchial cells. It potently inhibits endogenous cholesterol synthesis with an IC50 of 350 nM. This metabolite serves as a valuable research tool for studying oxidative stress responses, lipid metabolism disruption, and cellular toxicity in pulmonary models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 13027-33-3
• MW: 418.662
• Formula: C₂₇H₄₆O₃
• SMILES: [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC(=O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

159461