5-HT7/5-HT2A receptor antagonist 1

SKU: orb3173743

Description

5-HT7/5-HT2A receptor antagonist 1 is a high-affinity, orally active compound capable of crossing the blood-brain barrier, serving as a ligand for both 5-HT7 and 5-HT2A receptors with a pKi of 8.1 at each receptor. It acts as an antagonist in vitro in 5-HT2A functional assays and as an inverse agonist in 5-HT7 functional assays. This compound blocks hypothermia in rats induced by 5-Carboxamidotryptamine (5-CT) and prevents head twitches in mice caused by 2,5-Dimethoxy-4-iodoamphetamine (DOI). Additionally, it occupies 5-HT2A receptor binding sites in the frontal cortex of rat brains and is applicable in the study of neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 851375-22-9
• MW: 273.36
• Formula: C₁₆H₂₀FN₃
• SMILES: FC=1C=CC(=CC1)C2=C3C(=NN2C(C)C)CCNCC3
• Target: 5-HT Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor