5-HT6 inverse agonist 1

• Catalog Number: orb2814157
• Category: Small Molecules
• Description: 5-HT6 inverse agonist 1 (Compound 33) is an antagonist of the 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. This compound can inhibit 5-HT6R-mediated Cdk5 and mTOR signaling pathways and reduce tactile allodynia induced by spinal nerve ligation (SNL) in rat models.
• MW: 498.4
• CAS Number: 2727088-38-0
• Formula: C₂₂H₂₂Cl₂FN₃O₃S
• SMILES: Cl.O=C(NC1CCNCC1)C=2C=CN(C2C=3C=CC(F)=CC3)S(=O)(=O)C=4C=CC=C(Cl)C4
• Storage: -20°C
• Note: For research use only