5'-Fluoroindirubinoxime

SKU: orb1299042

Description

5'-Fluoroindirubinoxime (5'-FIO) is a potent and selective small molecule inhibitor of FLT3 tyrosine kinase, exhibiting an IC50 of 15 nM. It is a valuable research tool for investigating FLT3-driven signaling pathways in acute myeloid leukemia (AML), applicable in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 861214-33-7
• MW: 295.27
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₀FN₃O₂
• SMILES: O\N=C1\C(\Nc2ccccc\12)=C1/C(=O)Nc2ccc(F)cc12
• Target: FLT
• Solubility: DMSO:83.33 mg/mL (282.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.18 mM)

Bioactivity

• Target IC50:
  FLT3:15 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RK3E-ras, SNU-638, HT-1080, Inhibitor, Fms like tyrosine kinase 3, FLT3, inhibit, CD135, Cluster of differentiation antigen 135, A549, 5' Fluoroindirubinoxime, 5'-FIO, 5'Fluoroindirubinoxime, 5'-Fluoroindirubinoxime

Compound Identifiers

PubChem CID

135398503