5-Fluoro-UTP

• Catalog Number: orb64970
• Category: Tools
• Description: 5-Fluoro-UTP
• CAS Number: 3828-96-4
• Concentration: 100 mM-110 mM
• Form/Appearance: solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5
• Purity: ≥ 95% (HPLC)
• MW: Theoretical MW: 502.13 g/mol (free acid); Detected MW: 501.96 g/mol (free acid)
• SMILES: OP(=O)(O)OP(=O)(OP(=O)(OC[C@@H]1[C@H]([C@@H](O)[C@H](n2cc(F)c(=O)[nH]c2=O)O1)O)O)O
• Formula: C₉H₁₄N₂O₁₅P₃F
• Target: 5-Fluoro-UTP
• Hazard Information: Non-Toxic
• Storage: Store at -20 °C. Short term exposure (up to 1 week cumulative) to ambient temperature possible.
• Note: For research use only
• Application notes: Inhibition of viral application; Mutagenic activity; Conformational studies (NMR-NOE) of HIV-2 TAR-RNA; Use as NMR-label (F); X-ray of viral RNA polymerase. < br>< b>Spectroscopic Propertie: λmax 267 nm, ε 10.0 L mmol-1 cm-1 (Tris-HCl, pH 7.5).
• Expiration Date: 12 months from date of receipt.

References

Susanta Chatterjee 1, Parisa Naeli 1, Okan Onar 1 2, Nicole Simms 3, Aitor Garzia 4, Angela Hackett 1, Kelsey Coyle 1, Patric Harris Snell 1, Tom McGirr 1, Tanvi Nitin Sawant 1, Kexin Dang 3, Zornitsa Vasileva Stoichkova 3, Yumna Azam 1, Mark P Saunders 3, Michael Braun 3, Tommy Alain 5, Thomas Tuschl 4, Simon S McDade 1, Daniel B Longley 1, Christos G Gkogkas 6, Colin Adrain 1, John R P Knight 3, Seyed Mehdi Jafarnejad 1 Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil Nucleic Acids Res, (2024)

PubMed: 39351862

Chemical Structure of 5F-UTP