5-Feruloylquinic acid

SKU: orb1297485

Description

5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, making it a candidate for aging-related disease research. Studies indicate its potential in models of metabolic and neurodegenerative disorders, supporting its investigation in both in vitro and in vivo experimental systems.

Research Area

Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 40242-06-6
• MW: 368.34
• Purity: 99.11% (May vary between batches)
• Formula: C₁₇H₂₀O₉
• SMILES: COc1cc(\C=C\C(=O)O[C@@H]2C[C@](O)(C[C@@H](O)[C@@H]2O)C(O)=O)ccc1O
• Target: Sirtuin,Tyrosinase
• Solubility: DMSO:33.33 mg/mL (90.49 mM)

Bioactivity

• In Vitro:
  Traditional Chinese Medicine (TCM) compounds were employed for screening potent Sirt1 agonists, and molecular dynamics (MD) simulation was implemented to simulate ligand optimum docking poses and protein structure under dynamic conditions. TCM compounds such as (S)-tryptophan-betaxanthin, 5-O-Feruloylquinic acid, and RosA exhibited good binding affinity across different computational methods, and their drug-like potential were validated by MD simulation. Docking poses indicate that the carboxylic group of the three candidates generated H-bonds with residues in the protein chain from Ser441 to Lys444 and formed H-bond, π-cation interactions, or hydrophobic contacts with Phe297 and key active residue, His363. During MD, stable π-cation interactions with residues Phe273 or Arg274 were formed by (S)-tryptophan-betaxanthin and RosA.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5 Feruloylquinic acid, 5-O-Feruloylquinic acid, 5Feruloylquinic acid, 5-Feruloylquinic acid, 5-FQA, inhibit, Inhibitor, Sirt1, Tyrosinase

Compound Identifiers

PubChem CID

10133609