5-Aminouridine

SKU: orb1308880

Description

5-Aminouridine is a nucleoside analog that incorporates into DNA and modifies nucleobases. It exhibits research applications in oncology, virology, and mycology due to its reported growth-inhibitory properties against tumors, viruses, and fungi in various experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 2149-76-0
• MW: 259.22
• Purity: >99.99% (May vary between batches)
• Formula: C₉H₁₃N₃O₆
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(N)=C2
• Target: Influenza Virus,Antifungal,Nucleoside Antimetabolite/Analog
• Solubility: DMSO:55 mg/mL (212.17 mM)

Bioactivity

• In Vivo:
  5-Aminouridine inhibits the incorporation of carbamoylaspartate into pyrimidines in living rat RNA and DNA, and the incorporation of [32P]phosphate into phospholipids and RNA nucleotides in rat liver slices and liver cancers .
• In Vitro:
  5-Aminouridine inhibits the incorporation of carbamyl aspartate into pyrimidines of both RNA and DNA in rat lived and [32P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma. 5-Aminouridine must exhibit a low potential to be oxidized by Os(bpy)33+. The modified nucleobase is inserted into the target DNA by direct synthesis using modified phosphoramidites.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fungal, InfluenzaVirus, Influenza Virus, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Nucleoside Antimetabolite, Analog, 5-Aminouridine, 4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)

Compound Identifiers

PubChem CID

11276944