5-ALA benzyl ester hydrochloride

SKU: orb1307121

Description

Benzyl-ALA hydrochloride is a protoporphyrin IX (PPIX) precursor used as a photodetection agent in research. It has been shown to induce PPIX accumulation in colon carcinoma cell lines in vitro, supporting its investigation in photodynamic therapy and cancer imaging studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 163271-32-7
• MW: 257.71
• Purity: 99.38%
• Formula: C₁₂H₁₆ClNO₃
• SMILES: Cl.NCC(=O)CCC(=O)OCc1ccccc1
• Target: Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (19.4 mM);DMSO:245 mg/mL (950.68 mM);H2O:95 mg/mL (368.63 mM)

Bioactivity

• In Vivo:
  In female CBA/Gy mice, 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v.; 1h) results in a dose-dependent reduction in tumour porphyrin levels.
• In Vitro:
  In colon carcinoma cell lines SW480, 5-ALA benzyl ester hydrochloride (0.6-0.12 mM; 3h) induces PPIX accumulation.
• Animal Research:
  Animal Model: Female CBA/Gy mouse (CaNT tumour model) Dosage: 31 mg/kg Administration: i.v. ; 1 hours

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

colon, Benzyl-ALA hydrochloride, Benzyl-ALA Hydrochloride, Benzyl-ALA, 5 ALA benzyl ester hydrochloride, 5-ALA benzyl ester, 5ALA benzyl ester hydrochloride, 5-ALA benzyl ester Hydrochloride, accumulation, carcinoma, Inhibitor, Human Endogenous Metabolite, Endogenous Metabolite, EndogenousMetabolite, inhibit, protoporphyrin, photodetection, SW480

Compound Identifiers

PubChem CID

22253144