4SC-203

SKU: orb1298072

Description

4SC-203 is a potent and selective multi-kinase inhibitor targeting Flt3, Axl, ALK, and related receptors with low nM activity. It has demonstrated anti-proliferative effects in cellular assays and shows promise in preclinical models for oncology research, particularly in leukemia and solid tumors.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 895533-09-2
• MW: 642.77
• Purity: 99.98% (May vary between batches)
• Formula: C₃₃H₃₈N₈O₄S
• SMILES: COc1ccc(C)cc1NC(=O)Nc1nc2ccc(Nc3ncnc4cc(OCCCN5CCN(C)CC5)c(OC)cc34)cc2s1
• Target: VEGFR,FLT
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vivo:
  In preclinical studies, 4SC-203 demonstrated significant antitumor activity in in vivo models relevant to acute myeloid leukemia. In a first-in-human study in healthy volunteers, 4SC-203 was shown to be well tolerated across the concentration range studied and to have a favorable pharmacokinetic profile.
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• In Vitro:
  4SC-203 exhibits unique selectivity in the low nM range for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fms like tyrosine kinase 3, FLT3, FLT3/STK1, Inhibitor, inhibit, multikinase, 4SC 203, 4SC203, 4SC-203, antineoplastic, CD135, Cluster of differentiation antigen 135, tumor, Vascular endothelial growth factor receptor, VEGFR

Compound Identifiers

PubChem CID

44467821