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(4R,5S)-nutlin carboxylic acid

SKU: orb1988417

Description

This compound, derived from Nutlin-3, is a high-affinity (4R,5S)-configured MDM2 ligand. It serves as a key building block for constructing PROTAC degraders, enabling targeted protein degradation research in cancer and other disease models both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2306390-08-7
MW639.53
FormulaC32H32Cl2N4O6
SMILESC(=O)(N1[C@]([C@](N=C1C2=C(OC(C)C)C=C(OC)C=C2)(C3=CC=C(Cl)C=C3)[H])(C4=CC=C(Cl)C=C4)[H])N5CC(=O)N(CC(O)=O)CC5
TargetOthers,Ligands for E3 Ligase,PROTAC Linker

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information