4E1rcat

SKU: orb1307557

Description

4E1RCat is a small molecule dual inhibitor that disrupts the eIF4E interactions with both eIF4G and 4E-BP1, exhibiting an IC50 of 3.2 µM against eIF4G binding. It serves as a valuable research tool for studying cap-dependent translation initiation in cancer and cellular proliferation assays, both in vitro and in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 328998-25-0
• MW: 478.45
• Purity: 99.47% (May vary between batches)
• Formula: C₂₈H₁₈N₂O₆
• SMILES: OC(=O)c1ccc(cc1)N1C(=O)\C(=C\c2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)C=C1c1ccccc1
• Target: PERK,Autophagy
• Solubility: DMSO:23.9 mg/mL (49.95 mM)

Bioactivity

• Target IC50:
  eIF4G:3.2 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, 4E1rcat, 4E-1rcat, Inhibitor, inhibit, eIF-4E, Eukaryotic Initiation Factor (eIF)

Compound Identifiers

PubChem CID

16195554