4A3-SCC-10

SKU: orb3033124

Description

4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.

Key Properties

• MW: 1948.1
• Purity: >95%
• Formula: C₉₁H₁₇₁N₃O₁₆S₁₂
• SMILES: O=C(OCCSSCCOC(C(C)CCSCCCCCCCCCC)=O)CCN(CCCN(C)CCCN(CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CCSCCCCCCCCCC)=O)=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only