4A3-SC8

SKU: orb2278557

Description

4A3-SC8 is a modular dendritic macromolecule designed for nucleic acid delivery, combining cationic and lipophilic properties. It effectively formulates lipid nanoparticles to deliver small RNAs, demonstrating efficacy in extending survival in aggressive hepatocellular carcinoma models in vivo. This makes it a valuable tool for oncology and gene therapy research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1857340-78-3
• MW: 1467.18
• Purity: 99.87% (May vary between batches)
• Formula: C₇₅H₁₃₉N₃O₁₆S₄
• SMILES: O=C(OCCOC(=O)C(C)CSCCCCCCCC)CCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC
• Target: Liposome
• Solubility: DMSO:80 mg/mL (54.53 mM)

Bioactivity

• In Vivo:
  After intravenous injection of 1 mg/kg siRNA, 4A3-SC8 mediated the primary accumulation of siRNA in the liver, with lesser amounts in the spleen and kidneys, and resulted in greater than 95% knockdown of FVII in mice . Following administration of 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), the mice exhibited illness and a significant weight loss of nearly 20% on the first day post injection .
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• In Vitro:
  4A3-SC8 (100 mg/kg) is a biodegradable dendrimer with low toxicity and high delivery efficiency in mice carrying invasive liver cancer.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Liposome, 4A3 SC8, 4A3SC8

Compound Identifiers

PubChem CID

129092706