4A-BFA-11

SKU: orb3175064

Description

4A-BFA-11 is a folate-targeted PEG-MMAE conjugate with specific binding affinity for the folate receptor α (FR-α) (KD= 106.7 nM). It achieves tumor accumulation by combining PEG-mediated long circulation (EPR effect) with folate receptor targeting. At the tumor site, 4A-BFA-11 undergoes enzymatic cleavage to release the active payload, ensuring precise action. In HeLa mouse models, 4A-BFA-11 effectively delivers, targets, and regulates the release of MMAE within tumor tissues. This compound can be applied in research involving cervical cancer, ovarian cancer, and lung cancer.

Key Properties

• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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