4,5-Dimethoxycanthin-6-one

SKU: orb1683534

Description

4,5-Dimethoxycanthin-6-one is a bioactive alkaloid isolated from Picrasma quassioides. It exhibits antimicrobial activity against Staphylococcus aureus and demonstrates cytotoxicity against tumor cell lines like U937 and HepG2. This compound also acts as a potent, non-competitive inhibitor of CYP1A2 and cAMP phosphodiesterase.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 18110-87-7
• MW: 280.28
• Purity: 98.93% (May vary between batches)
• Formula: C₁₆H₁₂N₂O₃
• SMILES: COc1c(OC)c(=O)n2c3ccccc3c3ccnc1c23
• Target: Cytochromes P450,PDE,Antibacterial
• Solubility: DMSO:9 mg/mL (32.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.57 mM)

Bioactivity

• Target IC50:
  CYP1A2:2.6 μM (Ki)|CYP1A2:1.7 μM
• In Vitro:
  4,5-Dimethoxycanthin-6-one demonstrates strong and uncompetitive inhibition against CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4,5-Dimethoxycanthin-6-one, Bacterial, Antifection, cAMP, CAMP PDE, CYP1A2, Cytochrome P450, Methylnigakinone

Compound Identifiers

PubChem CID

638215