4,5-Dicaffeoylquinic acid

SKU: orb1222017

Description

Isochlorogenic acid C(4, 5) has antiviral activity, including anti-HIV-1 integrase activity. Isochlorogenic acid C(4, 5) shows anti-hepatotoxic activity.

Key Properties

• CAS Number: 57378-72-0
• MW: 516.45
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₄O₁₂
• SMILES: C1C(C(C(CC1(C(=O)O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)OC(=O)C=CC3=CC(=C(C=C3)O)O)O
• Target: Others
• Solubility: DMSO : 50 mg/mL 96.81 mM

Bioactivity

• In Vivo:
  4, 5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice.
• In Vitro:
  4, 5-Dicaffeoylquinic acid (0.1~100 μM; 72 h) has dose-dependent inhibitory activity against DU-145 prostate cancer cells, and induces cell cycle arrest, also induces inactivation of Bcl-2.4, 5-Dicaffeoylquinic acid (1~100 μg/mL; 48 h) has anti-apoptotic effect in D-GalN-challenged HL-7702 hepatocytes, and improves significantly cell viability at concentrations of 10 to 100 μg/mL.4, 5-Dicaffeoylquinic acid (1~100 μg/mL; 4 days) inhibits significantly expressions of HBsAg and HBeAg, and produces the maximum inhibition rates of 86.93 and 59.79% at 100 μg/mL on expressions of HBsAg and HBeAg, respectively. Cell Proliferation Assay Cell line: DU-145 cells. Concentration: 0.1~100 μM Incubation time: 72 h. Result: Exhibits dose-dependent inhibitory activity against DU-145 prostate cancer cells with an IC50 of 5 μM. Cell Cycle Analysis Cell line: DU-145 cells. Concentration: 5 μM. Incubation time: 72 h. Result: Decreased in numbers in G0/G1 phase and increased in S phase. Apoptosis Analysis Cell line: HL-7702 hepatocytes (exposure to 60 mM D-GalN for 6h). Concentration: 1~100 μg/m L. Incubation time: 48 h. Result: Significantly reduced the caspase-3 and transforming growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes at 10~100 μg/mL. Cell Viability Assay Cell line: HL-7702 hepatocytes (exposure to 80 mM D-GalN for 6h). Concentration: 1~100 μg/mL. Incubation time: 48 h. Result: Improved significantly cell viability at concentrations of 10 to 100 μg/mL, and produced a maximum protection rate of 47.28% at 100 μg/mL.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isochlorogenic acid C

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Gene Symbol

Others